A Novel Gadolinium-Based Contrast Agent Targeted to Cathepsin-D
نویسندگان
چکیده
slice images of Gd-DTPA, Gd-DOTACAT and 10% BSA at 37oC at 9.4T. Figure 2. Relaxation rate (R1 = 1/T1) as a function of concentration. Gd-DOTACAT has a greater relaxivity 6.9 (mM s) than clinically used Gd-DTPA (Magnevist®) of 3.2 (mM s). Figure 3. Signal intensity plots from 3 regions of interest: brain tissue, cerebral and non-cerebral blood vessels. There was an increase in signal intensity within all regions of interest post-injection of Gd-DOTACAT. 3+
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